Advanced Signal Processing for Target
Enumeration and Localization in Multiple-Input
Multiple-Output Radar
Hong Kong Principal Investigator: Dr SO
Hing Cheung (The City University of Hong
Kong)
Mainland Principal Investigator: Dr HUANG
Lei (Harbin Institute of Technology)
Radar is an acronym for radio detection and ranging system. Multiple-input multiple-output (MIMO) radar is an emerging technology which uses a number of spatially separated transmitters and receivers to simultaneously transmit radio waves and to receive the reflected signals for joint processing, respectively, in order to achieve the important tasks of target detection, positioning and imaging. Unlike the conventional phased-array radar which can only transmit scaled versions of a single waveform, the transmit antenna arrays of the MIMO radar are capable of emitting independent and orthogonal signals. The waveform diversity in the MIMO radar paradigm has been shown to offer better identifiability (that is, more targets can be uniquely identified) and higher spatial resolution (that is, more closely-spaced targets can be resolved) over the phased-array counterpart, which leads to significant improvements in signal detection and parameter estimation performance. Nevertheless, many research challenges need to be tackled to advance MIMO radar from concept to reality. For example, a key difficulty is to achieve optimum detection and estimation performance particularly when the signal-to-noise ratio is low or the number of snapshots is small. Furthermore, processing of the multi-dimensional radar data corresponds to enormous computations and thus algorithm complexity is a main concern.
The aim of this research is to devise advanced
signal processing approaches for determining
the number of targets and finding their
positions in an accurate and computationally
efficient manner by exploiting the special
structure inherent in the MIMO radar signals.
In particular, we will utilize random matrix
theory for target detection and base on
the subspace approach as well as tensor
algebra for localization algorithm development.
The performance of the devised methods will
also be analyzed and evaluated for various
MIMO radar application models.
Theoretical and Experimental Study of
Quantum Computing and Quantum Simulation
with Electron and Nuclear Spins in Solids
Hong Kong Principal Investigator: Prof.
Liu Renbao (The Chinese University of Hong
Kong)
Mainland Principal Investigator: Prof. Du
Jiangfeng (University of Science and Technology
of China)
Quantum computers will mark a new era of
information technology. The physical implementation
of scalable quantum computers is the central
topic of current research of quantum information.
Among various candidate systems, spins in
solids are most promising due to their stability,
integrability, and compatibility with existing
nanotechnologies. Quantum simulation of
interacting many-body systems has been the
first motivation and is still a most challenging
task for research of quantum computing.
With synergy of theoretical and experimental
efforts, this project targets at physical
implementation of few-qubit quantum computing
and quantum simulation using electron and
nuclear spins in solids. The key issues
in solid-state quantum computing and simulation
are how to protect quantum coherence and
implement high-fidelity quantum gates in
complex solid-state environments and how
to scale up the system and control design.
This project will tackle these important
problems by a combination of theoretical
and experimental approaches. We will (i)
design and demonstrate one- and two-qubit
quantum gates of electron and nuclear spins
in noisy environments, including non-Abelian
geometrical control of spin qubits; (ii)
design and demonstrate small quantum algorithms
and simulations of quantum phase transitions
using a few spin qubits in solids, using
pulsed magnetic resonance; and (iii) design
of scalable architectures of spin-based
solid-state quantum computers.
The specific physical system to be investigated
in this project will be mostly carbon-based
solid-state materials, especially diamond,
where the spins have long coherence time
even at room temperature thanks to the weak
spin-orbit interaction in the light-element
materials. The experimental techniques include
pulse electron paramagnetic resonance, solid-state
nuclear magnetic resonance, and optically
detected magnetic resonance of single spins,
all of which have been readily grasped by
the experimental team. The theoretical methods
include many-body theories of spin dynamics
in nano-systems, quantum information approaches
to quantum phase transitions, exact solutions
of few-spin systems, dynamical decoupling
theories of coherence protection, and geometrical
control of spin systems. All such theories
have been developed with significant contributions
from the theoretical team.
In the long term, this project will pave
the way for scalable quantum computing in
solid-state spin systems. Furthermore, the
research in this project may also rejuvenate
high-precision magnetic resonance spectroscopy,
an information acquisition tool widely used
in physics, chemistry, materials science,
biology and medicine.
Towards Trustworthy Cloud Computing
with Component-based Design, Online Evaluation,
and Runtime Optimization Techniques
Hong Kong Principal Investigator: Prof.
Lyu Michael R (The Chinese University of
Hong Kong)
Mainland Principal Investigator: Prof. Wang
Huaimin (National University of Defense
Technology)
Cloud computing is Internet-based computing,
whereby shared resources, software and information
are provided to computers and other devices
on-demand, like a public utility. With powerful
technical and commercial support by leading
industrial companies (e.g., Amazon, Google,
Microsoft, IBM, etc.), cloud computing is
quickly becoming popular in recent years.
Cloud applications are often large-scale
systems, composed of a number of heterogeneous
and distributed cloud components. Providing
trustworthy computing is becoming centric
to such an emerging computing paradigm,
incurring various important and urgent research
problems. In particular, it is critical
for cloud computing platforms to provide
users with reliable and secure Internet-based
computing facilities, so that users are
willing to put their data and services on
the clouds. This project will tackle the
major challenges of building trustworthy
cloud applications.
A series of research tasks will be conducted
in this project. First we attempt to achieve
cloud fault prevention in system design
and deployment phases via vulnerable cloud
component identification and cloud node
quality prediction. Upon releasing of cloud
applications, we detect robustness, Quality-of-Service
(QoS), and functional problems of cloud
applications via online evaluation techniques
tailored for cloud computing. After identifying
the robustness, QoS, and functional problems
of cloud applications, we focus on system
runtime optimizations by system reconfiguration,
reputation mechanisms, and new access controls.
A systematic trustworthy cloud computing
environment is consequently established.
Finally, we conduct experimental verification,
implementation, and release of our research
outputs and tools to the community.
This project will enable us to build secure
and reliable cloud applications efficiently
and effectively in the dynamic cloud execution
environment. Practical and systematic trustworthy
cloud computing techniques will not only
promote the development of cloud computing
research, but also enable the establishment
of industrial practice in applying these
techniques to various service-oriented business
and finance sectors. By joining force with
our mainland China partner, the project
can help to maintain Hong Kong's preeminent
status as one of the world's major service
centers. As a tangible outcome, the proposed
techniques of this project will be encapsulated
into a toolkit, which will be widely released
to industry and academia.
Theory and practice of large-scale 3D
urban reconstruction and modeling
Hong Kong Principal Investigator: Prof.
Long Quan (HKUST)
Mainland Principal Investigator: Prof. Baoquan
Chen (Shenzhen Institutes of Advanced Technology,
CAS)
The objective of the project is to investigate
a hybrid methodology for the three-dimensional
modeling of urban scenes using both two-dimensional
color images captured by cameras or videos, and
three-dimensional point clouds captured
by laser scanners. Both active and passive
sensors are jointly mounted on a moving
platform, and the captured image data and
point clouds are consistently registered
with the help of GPS and/or INS. The approach
first segments, recognizes, and decomposes
the large-scale input into small-scale object-level
representations of a specific category.
After that, each category of objects is
submitted to a modeling method of the category
by integrating the strong prior knowledge
of the underlying category information.
One unifying theme of this family of object
modeling methods is that each category of
objects is described by its own generative
models, which is the key to the efficiency
and the robustness of the modeling methods.
Finally, the approach will produce both
detailed geometry and an appearance representation
of the cities which are suitable for viewing
both on the ground level as 'road view'
or 'street view' and from the air as ¡¥bird¡¦s
eye view¡¦ his project is built
on our recent achievements in 3D modeling
of urban scenes. The two collaborating research
teams of the HKUST and the SIAT have been
the most active groups n recent years in
3D city modeling. The HKUST group has focused
on the image-based approach to leverage
its expertise in computer vision, while
the SIAT has focused on canner-based approach
to leverage its geometry processing expertise
in computer graphics.
The Minimized Energy Consumptions and
Maximized Resource Utilizations in Large-scale
Datacenters
Hong Kong Principal Investigator: Dr. Bo
Li (HKUST)
Mainland Principal Investigator: Dr. Zhiyong
Liu (Inst. of Computing Technology, CAS)
Datacenters within the ¡§cloud¡¨
of the Internet are providing support for
a large variety of applications ranging from
e-commerce, scientific computing, virtual
desktop, to online hosting and social network
applications. Such platforms consume a significant
amount of energy, due to their massive scale
and redundancy in order to meet reliability
and performance guarantees. This is further
aggravated by the fact that the resource
utilization in operational datacenters appears
to be remarkably low, and in some cases
a mere 10%. Apparently, such under-utilized
resources in the dimensions of CPU cycles,
network bandwidth, disk storage and memory
can lead to a substantial waste of capital
investment.
Despite the wide deployment of operational datacenters, there is a lack of systematic study on characterizing the dynamic time-varying workload, the fundamental requirement and constraints towards energy and resource optimization. In addition, there are few practical algorithms that incorporate recent advances in virtualization technology and dynamic task migration towards unified optimization of energy efficiency and resource utilization. While existing research has largely focused on optimizing isolated components, in this project, we propose to design a multi-objective optimization framework that aims to maximize resourceutilization and minimize energy consumption. Specifically, we will (1) carry out an extensive measurement study to capture the time-varying workload characteristics of different applications; (2) establish a theoretical framework demonstrating the critical factors that influence the optimization of energy and resource utilization and the fundamental performance trade-offs; and (3) design practical task scheduling and dynamic migration algorithms that can achieve energy efficiency and optimal resource utilization simultaneously. This not only can establish a solid theoretical foundation toward joint optimization of energy and resource usages, but also offer practical guidelines for the design of energy-efficient algorithms towards better resource utilization.
In light of rapid development and deployment of cloud computing services and datacenters in Hong Kong and China, we believe this timely research not only bears tremendous academic significance, but also holds great potential in practical system implementations.
Photochemical properties of endogenous
biological molecules: fundamental and application
Hong Kong Principal Investigator: Prof.
Jiana Qu (HKUST)
Mainland Principal Investigator: Prof. Yi
Luo (Hefei National Lab. for Physical Science
at the Microscale)
This proposed project is a multidisciplinary
research of high relevance to optical physics,
chemistry, life science and engineering.
It is encouraged by a recent
successful collaboration between the Hong
Kong and mainland PIs' research groups which
led to a major discovery of two-photon excitation
fluorescence (TPEF) of hemoglobin, an essential
protein responsible for oxygen transport
in blood1. Subsequently, the two PIs' groups
have worked together to develop TPEF microscopy
for in vivo label-free imaging of microvasculature
in tissue based on the high-energy fluorescence
of hemoglobin. We have successfully demonstrated
that two-photon excited hemoglobin fluorescence
provides a contrast mechanism for label-free
imaging of microvasculature in vivo at the
tissue level2. This conceptually new discovery
of hemoglobin fluorescence is expected to
significantly impact the medical diagnosis
of blood diseases and disorders, and the
development of new fluorescence probes for
biological imaging. The success was a result
of having a good understanding of the photochemical
properties of hemoglobin, the optimal instrumentation
for the efficient excitation and collection
of hemoglobin fluorescence signals from
biological samples. In the proposed research,
we will first conduct a series of theoretical
and experimental studies to fully understand
the unique TPEF characteristics of hemoglobin.
Furthermore, we will develop the design
strategy and synthesize a new class of fluorescent
probes for biological imaging based on the
knowledge obtained in the study of photochemical
properties of hemoglobin. The new probe
will have a similar molecular structure
to hemoglobin, but will be optimized for
commonly used commercial excitation sources
and detection systems. More importantly,
the new probes, like the endogenous and
non-toxic hemoglobin itself, should introduce
minimal disturbance to the biological system
of interest being imaged. The proposed research
takes advantages of the Hong Kong team's
experiences in the development of advanced
optical imaging technology for biomedical
applications and the Mainland team's experiences
in the theoretical modelling of photochemical
properties of biological molecules, as well
as the design and synthesis of molecular
probes for life science research and medical
diagnosis.
From bone marrow cells to Schwann cells
- in vitro route to specification and utility
in re-myelination therapy
Hong Kong Principal Investigator : Professor
D.K.Y. Shum (The University of Hong Kong)
Mainland Principal Investigator : Dr Q.
Ao (Tsinghua University)
Our ultimate goal of in vitro derivation of Schwann cells from adult tissues is such that they may be used autologously in nerve guidance channels to assist post-traumatic nerve regeneration in both PNS and CNS. The bone marrow harbours renewable progenitor cells that can be tapped for directed differentiation in vitro. Existing protocols for derivation of Schwann cell-like cells (SCLCs) from bone marrow stromal cells (BMSCs) fall short in stability of the acquired phenotype and the functional capacity to myelinate axons. Our preliminary experiments with rat cells indicated that neuro-ectodermal progenitor cells among the BMSCs can be selectively expanded in neurosphere- forming condition and then induced to differentiate to SCLCs in adherent culture. Coculture of the SCLCs with embryonic dorsal root ganglion (DRG) neurons can accomplish fate commitment of the Schwann cells.
In transition to a human protocol for clinical application, a limiting factor is the source of sensory neurons that provide cues necessary for Schwann cell fate commitment. Under Objective 1, this will be addressed by deriving human sensory neurons from induced pluripotent stem cells (iPSCs) and to use these as alternative to DRG neurons to signal the switch to fate commitment. Under Objective 2, we expect to design a new conduit based on uniaxially aligned chitosan nanofibres and heparan sulfate-supplemented medium to support the derived Schwann cells in a nerve bridge that improves axonal regrowth and remyelination. Under Objective 3, we expect to identify key neuronal membrane effector(s) that switch SCLCs to committed Schwann cells and look forward to engineering a neuronal surrogate for the protocol.
This project builds on the collaborative
effort of the Hong Kong PI (Shum) and CoI
(Chan) together with the Mainland PI (Ao).
Collaboration was initiated when Ao took
leave from Tsinghua University (Beijing)
to be a recipient of a Dr. Cheng Yu-Tung
Fellowship (2007-08) and later an International
Brain Research Organization (IBRO) Exchange
Fellowship (2009). Shum's group has made
the leap from neural tissue-derived Schwann
cells to BMSC-derived, fate-committed Schwann
cells for remyelination studies. Ao contributed
expertise in the production of hollow chitosan-based
conduits into which BMSC-derived Schwann
cells were seeded in Matrigel matrix. Chan's
group further complemented with electrophysiological
assessment of functional recovery of nerves
bridged with the cell-seeded conduit. These
provide us with an edge to pursue Schwann
cell derivation from human BMSCs towards
clinical application in nerve repair and
remyelination therapy.
Investigating the role of FOXM1 in the
maintenance of human embryonic stem cell
pluripotency and genome stability
Hong Kong Principal Investigator: Kwok-Ming
Yao (Department of Biochemistry/The LKS
Faculty of Medicine/The University of Hong
Kong)
Mainland Principal Investigator: Yongjun
Tan (Department of Biomedical Engineering/College
of Biology/Hunan University)
Stem cells have the ability to self-renew and differentiate into different fetal and adult cell types, a property referred to as pluripotency. The recent establishment of pluripotent human embryonic stem cell (hESC) lines and the successful reprogramming of differentiated cells into induced pluripotent stem cells (iPSCs) have laid the groundwork for "personalized" cell therapy and regenerative medicine. However, better understanding of the molecular basis of regulation of stem cell pluripotency and genome stability is essential before the full therapeutic potential of stem cells can be exploited.
The Forkhead box (FOX) transcription factor FOXM1, previously known as WIN, HFH-11, and Trident, is ubiquitously expressed in proliferating and regenerating cells. FOXM1 function is required for proper cell proliferation and FOXM1-depleted cells had difficulty executing mitosis, and exhibited chromosomal instability and polyploidy. However, its functional requirement in stem cells remains unclear since most studies were conducted using immortalized and cancer cell lines. Interestingly, Prof. Yongjun Tan (PI of the Mainland team) and his colleagues demonstrated recently that FoxM1 is required for the maintenance of pluripotency of mouse P19 embryonal carcinoma (EC) cells. FoxM1 directly regulates the pluripotency-related transcription factor Oct4 and overexpression of FoxM1 alone is enough to upregulate the pluripotent genes Oct4, Nanog and Sox2. Moreover, Prof. Tan has previously shown that FoxM1 is stabilized upon DNA damage, and its increased expression leads to stimulation of the expression of DNA repair genes, suggesting that FoxM1 is an effector of the DNA damage response to maintain genome stability. Independently, the laboratory of Dr. Yao (PI of the Hong Kong team) recently demonstrated that elevated FoxM1 levels protect mouse embryonic fibroblasts against oxidative stress-induced premature senescence.
Based on these recent findings, we hypothesize that FOXM1 is a master regulator that coordinate expression of various pluripotent and DNA repair genes to maintain proper human stem cell function. To address this hypothesis, we plan to investigate the role of FOXM1 in the maintenance of pluripotency and genome stability in hESCs. First, FOXM1-specific short hairpin RNAs will be expressed in the hESC line H9 using lentivirus-based vector to study the effect on the expression of pluripotent genes. The effect of FOXM1 overexpression in counteracting retinoid acid-induced H9 differentiation will also be explored. Moreover, FOXM1 will be tested for its ability to increase the efficiency of the Yamanaka factors in reprogramming mouse embryonic fibroblasts into iPSCs. Second, FOXM1 will be assessed for its requirement to protect H9 cells from oxidative stress-induced DNA damage by examining DNA breaks by immunostaining for γH2AX, 53BP1, and TUNEL foci. Third, to identify the FOXM1-centered protein-protein interaction network in H9 cells, protein complexes containing tagged FOXM1 will be affinity purified and analyzed by mass spectrometry using the in vivo metabolic biotin tagging method. Taken together, these analyses will shed new light into the regulation of hESC pluripotency and genome stability by FOXM1, which is a prerequisite to designing future strategies to optimize the performance of stem cells for cell therapy.
Functional Analysis of Isorhynchophylline
in Promoting Autophagy and Protecting Neurons
Hong Kong Principal Investigator: Dr. Li
Min (School of Chinese Medicine, Hong Kong
Baptist University)
Mainland Principal Investigator: Prof. Ma
Long (State Key Lab. of Medical Genetics
of China, Central South University)
Neurodegenerative diseases including Parkinson's disease (PD) and Alzheimer's disease (AD) are characterized by accumulation of abnormal protein aggregates in the affected regions of brain. Macroautophagy (autophagy) is a highly conserved process for cellular degradation of cytosolic contents including protein aggregates. Recent studies, using autophagy-defect transgenic mice, revealed a critical role of autophagy in the homeostasis of neurons. Targeting the autophagic pathway in the neuronal cells for the degradation of pathogenic protein aggregates has emerged as a novel and straightforward therapeutic strategy for neurodegenerative diseases. In our preliminary study we identified an autophagy inducer Isorhynchophylline (IRY) from a pool of Chinese medicinal compounds. We found that IRY can induce autophagy in neuronal cell lines (N2a, SH-SY5Y and PC12), primary neuron culture and Drosophila, and it can promote degradation of WT and mutant alpha-synuclein monomers, alpha-synuclein oligomers and alpha-synuclein /synphilin-1 aggresomes in neuronal cells. Given the protective role of autophagy in the neurodegenerative disease, our findings suggest that IRY may be an effective therapeutic agent for the treatment of neurodegenerative diseases including PD.
For a further understanding of the pharmacological
action and molecular mechanism of IRY-induced
autophagy, this study is aimed to achieve
the following objectives:
1. To understand the effects of IRY on
autophagy and neuroprotection using animal
models based on phenotypic analysis;
2. To examine the role of Beclin-1 complex
in the IRY-induced autophagy;
3. To identify the molecular targets of
IRY and novel genes mediating the effects
of IRY.
To accomplish our objectives, we will test
the pro-autophagic and neuroprotective effect
of IRY through multiple in vivo transgenic
PD models (Drosophila, C. elegans,
Mice), examine the role of Beclin-1 in the
activation of autophagy by IRY, identify
the molecular target(s) of IRY by chemical-proteomics
study and screen for genes mediating the
effects of IRY in C. elegans.
These results will help us understand the
underlying mechanism by which IRY induces
autophagy in neuronal cell and provide the
basis for the development of IRY into a
therapeutic agent for treating neurodegenerative
diseases.
Blocking HIV infection by gene encoding
neutralizing antibodies
Hong Kong Principal Investigator: Zhiwei
Chen, AIDS Institute and Department of Microbiology,
LKS Faculty of medicine, University of Hong
Kong
Mainland Principal Investigator: Paul Zhou,
Institut Pasteur of Shanghai/Chinese Academy
of Sciences
With over 27-years of effort, there is
still no effective vaccine or therapeutic
cure for AIDS. To find a solution, innovative
approaches should be comprehensively investigated.
Toward this end, since it is extremely difficult
to make a vaccine that can induce neutralizing
antibodies (nAbs), which can block viral
infection and spread, we aim to engineer
nAb genes that can then be produced in two
different forms. The first form is called
GPI-anchored nAbs, which will be presented
on the cell surface and display potent anti-HIV
activity to prevent viral entry into CD4+
T cells based on our preliminary studies.
Since a recent case study has demonstrated
the proof-of-concept that it is possible
to use HIV co-receptor CCR5-defective cells
to cure an infected individual, this form
may lead to a cure by generating cells resistant
to HIV by transducing target cells with
GPI-anchored nAbs. The second form is secretory
nAb. This form mimics natural nAbs and allows
us to optimize the gene for high levels
of nAb expression, which is essential for
protection. Since it has been demonstrated
in monkeys that the potent 2G12 nAb provides
full-protection against viral mucosal infection
even at low concentrations, the combined
use of potent secretory nAbs may provide
better protection to prevent HIV sexual
transmission with improved potency while
minimizing the emergence of nAb-resistant
viruses. We, therefore, hypothesize that
the combination of gene-encoding GPI-anchored
and secretory nAbs would have broader and
synergic effects in blocking diverse HIV
(or SHIV) infection and transmission while
minimizing the emergence of resistant mutant
viruses. To test this hypothesis, we propose
two specific aims: (1) To test the synergistic
effect of GPI-anchored and secretory nAbs
against large panels of multiclade HIV-1
pseudotypes and primary isolates in transduced
TZM.bl cells; (2) To test the synergistic
effect of GPI-anchored scFvs and secretory
nAbs against a large panel of multi-clade
HIV-1 primary isolates and SHIV in transduced
human T cell line or primary CD4 T and B
cells. By testing these two forms of gene-encoding
nAbs against a large panel of HIV-1 strains
especially isolated from local patients,
we seek to develop effective strategies
for future HIV treatment and prevention
in China as the first step and in the world
as the ultimate goal.
Induction of tolerance by alloantigen-specific
regulatory T cells in humanized mice and
non-human primates
Hong Kong Principal Investigator : TU Wenwei
(The University of Hong Kong)
Mainland Principal Investigator : CHEN Gang
(Huazhong University of Science and Technology)
Solid organ and bone marrow transplantations
are now widely accepted as an effective
treatment for end-stage failure of several
organs, and malignant and nonmalignant hematologic
diseases respectively. Although the treatment
with immunosuppressive drugs has undoubtedly
greatly improved graft survival, chronic
rejection still has considerable impact
on long term outcome. Moreover, most of
these drugs nonspecifically target the immune
response, leading to unwanted side effects.
The ideal in transplantation is, therefore,
the induction of a sustained state of specific
tolerance to alloantigen with minimal or
no conventional immunosuppression. Antigen-specific
regulatory T cells (Treg) play an important
role in maintaining immune tolerance by
suppressing pathologic immune responses.
Adoptive transfer of antigen-specific Treg
can prevent alloantigen-mediated T-cell
responses such as graft-vs-host disease
(GVHD) and allograft rejection but does
not compromise host general immunity in
rodents, indicating that antigen-specific
Treg-based therapy has substantial promise
for these diseases in humans. Recently we
have developed a simple and cost-effective
novel method to rapidly induce and expand
large numbers of functional human alloantigen-specific
CD4 Treg from antigenically-naive precursors
in vitro using allogeneic CD40-activated
B cells as stimulators. In this proposal,
we plan to investigate the therapeutic effects
of alloantigen-specific CD4 Treg induced
by CD40-activated B cells in humanized mouse
GVHD model and non-human primate kidney
transplantation, and define the underlying
mechanisms. This study will provide better
understanding of the role of human Treg
in the immune tolerance in vivo and develop
a more reliable and cost-effective protocol
to prevent GVHD and allograft rejection,
and accelerate Treg-based therapy in human.
Health Risk Assessment of Toxic Trace
Elements and Polycyclic Aromatic Hydrocarbons
(PAHs) via Indoor Dust from Coal-burning
Households in Rural China
Hong Kong Principal Investigator : Wong
Ming-hung (Croucher Institute for Environmental
Sciences, and Biology Department, Hong Kong
Baptist University)
Mainland Principal Investigator : Liu Wenxin
(College of Urban and Environmental Sciences,
Peking University)
As a "Coal Kingdom", the use
of coal for household cooking and heating
is common throughout China, especially in
rural areas. Due to epigenetic mineralization,
coal contains toxic trace elements such
as Ni, Cr, As, F, Pb and Hg, which could
not be destroyed during combustion, but
are released into air in their original
or oxidized form. In addition, the incomplete
combustion of domestic coal could result
in considerable polycyclic aromatic hydrocarbons
(PAHs) released into indoor air. The combustion
of coal therefore is the main source of
indoor air pollution and has had profound
adverse effects on the health of millions
of people in China. Chemical pollutants
could be adsorbed onto particulate matter
(PM) suspended in indoor air that later
settles out as indoor dust. However, there
are few studies which focus on investigating
the spatial and temporal patterns of toxic
trace elements and PAHs in indoor air, indoor
dust and PM from coal-burning households
in rural China and the
toxicity associated with indoor dust and
PM.
The present research will be carried out
in five purposely selected areas according
to the types of domestic energy used in
these households: Xuanwei Country, Yunnan
Province -Lung cancer epidemic area due
to indoor smoky (bituminous) coal combustion;
Guiding County, Guizhou Province and Ankang
County, Shaanxi Province - Rural households
using coal as their primary source of domestic
energy; Beijing and Hong Kong - Urban households
primarily using liquefied petroleum gas,
natural gas or electricity for cooking and
heating (as control). An intensive survey
consisting of questionnaires will be used
to investigate the status of indoor air
quality in coal-burning households in rural
China and to quantify the concentrations
of toxic trace elements and PAHs, Nitro-PAHs
and OH-PAHs in indoor air, PM and indoor
dusts. This will be followed by an investigation
to study the toxic effects of indoor dust
and PM on human airway cell lines (human
macrophage and bronchial epithelial cells)
(inhalation exposure), hepatoma cell lines
(ingestion exposure) and keratinocyte cell
lines (dermal contact) and to understand
the mutagenicity of PM and indoor dust from
coal-burning households in rural China.
The results generated from the present project
will uncover the different exposure pathways
to toxic trace elements andPAHs in indoor
air from coal-burning households in rural
China. The results will also serve as important
references for other parts of the world
suffering from similar problems.
Investigation of Heat and Mass Transfer
Mechanisms in a Novel Total Heat Exchanger
Hong Kong Principal Investigator: Prof.
NIU Jian-lei (Department of Building Services
Engineering, The Hong Kong Polytechnic University)
Mainland Principal Investigator: Prof. ZHANG
Li-zhi (Key Laboratory of Enhanced Heat
Transfer and Energy Conservation, South
China University of Technology)
The project is to investigate a novel Total
Heat Exchanger (THE) for heat and moisture
recovery from ventilation air for energy
saving in buildings. Total heat recovery
is a key technology for building energy
efficiency and CO2 emission reduction, especially
in hot and humid regions where cooling and
dehumidifying fresh air accounts for 20-40%
of the energy use for air-conditioning.
The novel THE uses one-step fabricated asymmetric
vapor permeable membranes (made from Cellulose
Acetate) which have very high vapour permeation
rates, and a cross-corrugated triangular
duct structure which has high convective
heat and mass transfer coefficients. The
research work will be conducted in the following
steps. (1) The heat and moisture transfer
model in the asymmetric membranes will be
set up using the fractal theory. (2) The
airflow, convective heat and mass transfer
characteristics in the cross-corrugated
triangular ducts under transitional flow
regime will be investigated experimentally
with Fourier Transformation analysis and
numerically with Large Eddy Simulation techniques.
(3) The overall heat and mass transfer model
of the novel THE, coupling the membrane
and duct airflow models, will be established.
(4) Using the model developed, patent designs
to intensify the overall heat and moisture
transfer in the THE will be investigated,
with the goal to achieve a sensible effectiveness
of 0.8 and a latent effectiveness of 0.7.
It is expected that application of the novel
total heat exchangers in air conditioning
systems in Pearl-River Delta region alone
will bring about 10.5 billion kWh electricity
save per year.
Biological Methanogenesis of Alkanes:
Thermodynamics and Microbial Ecology
Hong Kong Principal Investigator : Ji-Dong
Gu (The University of Hong Kong)
Mainland Principal Investigator : Bo-Zhong
Mu (East China University of Science and
Technology)
Energy shortage is a serious issue facing
all countries worldwide, but the situation
is devastated by nonrenewable nature of
petroleum supply. The reality is that when
a petroleum oilfield is closed down after
drilling and pumping with current available
technologies, there are still about 30-50%
of the total crude oil remaining as residues
due to tight binding to subsurface matrices
and high cost associated with extraction.
Subsurface environment is anaerobic due
to the lack of molecular oxygen (O2), anaerobic
bioconversion of petroleum hydrocarbons,
e.g., alkanes and aromatics, by indigenous
microorganisms can produce methane, the
natural gas. However, only a very limited
number of investigations including ours
have been reported on microbial population
capable of transforming alkanes from oil
reservoirs using molecular analysis, but
methanogenesis by microorganisms in oil
reservoirs has not been fully established
in terms of reaction rates. Methane production
from hydrocarbons involve consortium of
several groups of physiologically and biochemically
distinguished microorganisms to participate
in different parts of the biochemical conversion
steps from substrate compounds to organic
acids and then methane, by namely fermentative
bacteria, proton-reducing acetogens and
methane-producing archaea. Only by a close
association among them will they carry out
the methane production from hydrocarbon
successfully provided the anaerobic condition
is maintained. However, both microbial composition
and the rate of biochemical reactions are
very poorly understood at the moment for
oil reservoir systems. In a consortium capable
of producing methane, the balance of different
microbial groups is regulated and optimized
through the intermediate chemical produced,
particularly H2, its concentration allows
the thermodynamics balance between fermentative
process that produces H2 and the H2 consuming
ones for methanogenesis. Because of the
fundamental physical and chemical characteristics
of the methane-producing process, understanding
the thermodynamics of H2 on methanogenesis
of alkanes is the key basis before manipulation
of consortium composition and enhanced conversion
of petroleum hydrocarbons to methane can
be achieved. With this in mind, we would
like to use the methanogenic enrichment
cultures established in our joint laboratories
to further our in-depth investigations on
the microbial composition in these cultures
at different temperatures, the microbial
biochemical mechanisms involved and the
optimization of microbial composition for
accelerated methane generation. One key
question of this research is on why methanogenesis
can take place from alkanes to methane,
which will allow better assessment of the
biochemical reaction and control such process
for the enhanced reaction. At the same time,
the initial activation biochemical step
will be substantiated in this research project.
Investigating New Methodologies in Transportation
Service Procurement between Shippers and
Carriers
Hong Kong Principal Investigator: Prof Lim
Leong-chye Andrew (City University of Hong
Kong)
Mainland Principal Investigator: Prof Wang
Fan (Sun Yat-sen University)
Leveraging the extensive experience and
connections that the PI has with the large
shippers and carries, the project aims to
study various interesting operational aspects
on transportation service procurement. These
operational aspects include the quotation
process, the negotiation process, and the
optimization process. The outcome of this
project will be enhance shipper-carrier
collaboration and change the way procurement
is done for logistics in years to come.
Development of Smart and Uniform-sized
Colloidosomes for Drug Delivery
Hong Kong Principal Investigator : Prof.
Ngai To (The Chinese University of Hong
Kong)
Mainland Principal Investigator : Prof.
Ma Guang-hui (Institute of Process Engineering,
Chinese Academy of Science)
Colloidosomes are microcapsules that consist of a hollow core coated by a shell composed of self-assembled colloidal particles. In recent years, colloidosomes have received considerable attention because of their great potential as vehicles for the controlled delivery of active ingredients in medicine, home and personal care products, agrochemicals, and cosmetics.
However, even though examples of the practical usefulness of colloidosomes have been shown, their use as delivery systems has hitherto been extremely limited. This is because of the following three reasons: firstly, most previously described systems rely on the self-assembly of particles in the oil-water interface of a simple emulsion and they subsequently transfer to a different bulk phase to generate the colloidosomes, but the transfer step usually leads to microcapsule damage and a consequent low yield; secondly, the known colloidosomes are highly permeable and most of the cargo would already be lost before its target is reached; thirdly, the size distribution of colloidosomes produced is very broad, which does not make them commercially attractive for the encapsulation of active pharmaceutical and health ingredients where the delivery of an exact amount is crucial.
This proposal thus seeks a new method to create smart colloidosomes by templating from uniform-sized double emulsions. Monodisperse water-in-oil-in-water (W/O/W) double emulsions stabilized by pH-responsive nanoparticles will be prepared by using a membrane emulsification technique. The irreversibly adsorbed nanoparticles at the two oil/water interfaces can effectively inhibit the coalescence between the inner and outer water, and also protect an encapsulated cargo upon removal of middle oil phase, that is well in excess of what can be achieved by double emulsions stabilized by surfactants or polymers. More importantly, these two nanoparticle-covered interfaces will combine and lead to responsive colloidosome walls containing dual layers of nanoparticles, which will be very robust and in response to a pH triggering stimulus. The size of the double emulsions and consequently the dimensions of the resulting colloidosomes will be precisely controlled by the pore size of the membrane. The permeability, mechanical strength, and stimulus-triggered release of the colloidosomes will be adjusted and the potential applications of produced colloidosomes as bio-drug (e.g., insulin) carriers for oral administration will be exploited both in vitro and in vivo.
The successful accomplishment of this project will not only provide a general and robust strategy for microencapsulation, but will also result in the development of a novel orally administered drug carrier.
Air-surface Exchange of Persistent Organic
Pollutants (POPs) and Heavy Metals (HMs)
in Peri-urban Agricultural Ecosystems of
the Pearl River Delta, South China
Hong Kong Principal Investigator: Prof.
LI Xiangdong (PolyU)
Mainland Principal Investigator: Dr ZHANG
Gan (Guangzhou Institute of Geochemistry,
Chinese Academy of Sciences)
Persistent organic pollutants (POPs) are chemicals toxic to humans and wildlife. They are able to stay in the environment from months to decades, and can be distributed among different environmental media. The Stockholm Convention targeting source reduction and restriction of a number of POPs has been adopted by most countries and regions in the world. These chemicals include organochlorine pesticides (OCPs), such as DDTs and HCHs, and some emerging POPs, such as polybrominated biphenyl ethers (PBDEs) which are a group of brominated flame retardants (BFRs).
The accumulation of POPs and heavy metals
(HMs) in agricultural soils can lead to
deterioration in soil quality; this, in
turn, could post a threat to food safety
and human health. A peri-urban agricultural
ecosystem is susceptible to the receipt
of large amounts of toxic chemicals from
intensive human activities in nearby cities.
However, little is known of the accumulation
rates and fate of typical POPs in peri-urban
agricultural eco-systems, where intensive
industrialization and urbanization are taking
place. This is particularly the case with
regard to rice paddy fields, which occupy
a vast land area in Asian developing countries.
Such sites are becoming global industrial
bases as well as the target destination
of more than 90% of the world's e-waste.
The Pearl River Delta (PRD) region, including
Hong Kong and Macau, is in fact a city cluster
area with highly developed industrial operations.
These industrial operations and urban activities
have led to the release of large quantities
of pollutants into the environment, including
BFRs. The region has traditionally been,
and still remains, a very important agricultural
region in China. Past agricultural practices
have left high levels of residue of legacy
organochlorine pesticides (OCPs), such as
DDTs and HCHs in soils. Considering the
different input histories of 'old' OCPs
and 'new' BFRs, obtaining the understanding
of current air-surface exchange fluxes and
budgets in the peri-urban paddy fields of
this subtropical region is a matter of great
importance. In this proposed research project,
we aim to study the air deposition exchange
fluxes in typical paddy fields using a combination
of innovative field sampling programmes
and laboratory modelling experiments. This
will probably be the first systematic investigation
into the geochemical cycling of POPs in
one important type of agricultural soil
- paddy fields in a subtropical region.
The outcome of the project will contribute
to a better understanding of the biogeochemical
processes and dynamics of POPs in peri-urban
paddy ecosystems of a subtropical region,
and their potential impact on the global
fate of these chemicals. It will also shed
light on the important issues of regional
soil quality and food safety.
Design and synthesis of advanced functional
materials from microfluidic approaches
Hong Kong Principal Investigator: Prof.
Weijia Wen (HKUST)
Mainland Principal Investigator: Prof. Jianhua
Qin (Dalian Inst. of Chemical Physics, CAS)
This project involves the study of functionalized materials using microfluidic approaches. How to functionalize materials is a very challenging problem due to the complicated design and fabrication process. As we know, the conventional materials can be made via different synthesis methodologies physically or chemically.
However, materials with unique properties
such as smart materials are difficult to
produce using conventional techniques. Therefore,
a novel method needs to be developed for
such kind of material production. Specifically,
the fabrication of microsphere with different
configurations and complicated structures,
like
multilayered structures, can be easily generated
through microfluidic approaches. The design
and fabrication of artificially functionalized
materials through microfluidic approaches
has become a very hot research topic recently
not only within the microfluidics community
but also among researchers in various fields
like materials, physics, chemistry as well
as biology.
Based on our previous experiences in microsphere and nanoparticle design and fabrication, in this project, we will design and fabricate different types of microspheres with functionalized properties, in the meantime, the fabrication of nano-materials from microfluidic approaches will also be carried out in parallel. The characterization and applications of functional materials will be performed. We believe that the deliverables from this proposal will be a new knowledge on and a new fabrication methodology for artificial materials. It is predicted that these newly functionalized materials may eventually be utilized in some realistic applications influencing our future living, especially in biological, energy as well as other aspects. The long-term significance of this project is clear: the realization of a new class of smart/intelligent materials with endless applications.
New fluorescent sensors with aggregation-induced
emission characteristics
Hong Kong Principal Investigator: Prof.
Benzhong Tang (HKUST)
Mainland Principal Investigator: Prof. Zhen
Li (Wuhan University)
Scientists and technologists have devoted
much effort to the development of sensitive
and selective sensory systems for the detection
of chemicals, metals, and
biopolymers because they play important
roles in industrial, environmental and biological
processes and systems. Sensors based on
fluorescent materials have
attracted special attention, as they offer
high sensitivity, low background signals,
and wide dynamic ranges. However, it is
well-known that aggregation of conventional
luminophores often quenches light emission,
which limits the application scope of the
luminophores. This problem must be solved
because fluorescent materials are commonly
used as solid substances in commercial devices.
Various chemical, physical and engineering
approaches have been taken to interfere
with the fluorophore aggregation, but the
attempts have so far met with only limited
success. It would be perfect, if a system
can be developed, in which fluorescence
is boosted, instead of being quenched, by
aggregate formation.
In 2001, we discovered an unusual phenomenon
of aggregation-induced emission (AIE): a
series of propeller-shaped molecules named
siloles show faint or
no fluorescence in the solution state but
emit efficiently in the aggregate state.
The AIE effect boosts the emission efficiency
of the siloles by more than two orders of
magnitude, turning them into strong light
emitters. Since then, AIE fluorogens with
high quantum yields and full emission colors
have been developed. The AIE fluorogens
have been used for the fabrication of efficient
optoelectronic devices; in contrast, much
less work has been done on exploring their
applications in environmental and biological
sciences. In this research project, we plan
to develop new AIE systems with potential
applications in these areas. Our AIE approach
is novel and useful because it permits the
use of fluorogen solutions with any concentrations
and enables the development of turn-on sensors
with high sensitivities by taking advantage
of the fluorogen aggregation. To achieve
the project objective, we will team up with
an active research group led by Professor
Zhen Li at Wuhan University. New fluorogenic
materials with AIE feature will be generated
through innovative synthetic routes. Through
close collaboration, new synergy will be
developed and new avenues will be opened.
Research efforts and strengths of our team
in the area will be coordinated and cross-fertilized.
It is expected that this project will lead
to the development of new materials and
useful technology, which will help sharpen
the competitive edge of our local industry.
Mechanical-Electrical-Chemical Coupling
Properties of Nanoporous Metals
Hong Kong Principal Investigator: Prof.
Tongyi Zhang (HKUST)
Mainland Principal Investigator: Prof. Lijie
Qiao (Univ. of Science & Technology
Beijing)
Surfaces of solids play an essential role
in surface-chemistry-driven actuation, absorption,
catalysis, corrosion and dealloying, stress-charge
interactions, and
size-dependent behaviors. In nanomaterials
and nanoporous materials, the surface-to-volume
ratio is extremely large, which makes the
role of surfaces more
significant. Graphene, which is made of
a single layer of carbon, is an extreme
example, where all atoms are on the surface.
However, surfaces of solids behave differently
from surfaces of liquids because atoms in
solids cannot move quickly so that solids
have their own shapes and can sustain deformation,
which brings great academic challenge. To
satisfy academic curiosity and to bring
industrial innovation, it is necessary to
understand and predict the mechanical, electrical
and chemical coupling behaviors of nanomaterials
and nanoporous materials, which may exhibit
size-dependent properties when conventional
continuum thermodynamic theory is applied.
Although great progress has been achieved
in the research on the mechanical, electrical
and chemical coupling behaviors, there are
still some challenging issues, which hamper
the further development of thermodynamic
theory for nanomaterials and nanoporous
materials. Based on our rich research experiences
in surface stress and surface elastic constants
of solids, atomistic simulations, mechanical-electrical
coupling behaviors of bulk materials, electrochemistry,
corrosion, dealloying, hydrogen-induced
strain and stress, formation of porous metals,
stress corrosion cracking, etc, we propose
to study the mechanical-electrical-chemical
coupling properties of nanoporous metals.
The purpose of the proposed research is
to develop a nonlinear thermodynamic theory
to explain and predict the strain-charge-chemical
coupling behaviors of nanoporous metals.
To achieve this goal, we shall conduct experiments,
theoretical study, and atomistic simulations.
The designed nanobridge test on individual
samples with
well-defined geometry will generate reliable
experimental data about the strain-charge-chemical
behaviors of nanometer-sized metals. The
theoretical study
will consider nonlinear initial in-plane
deformation induced by relaxation of nanometer-thick
films. This will lay the foundation of nonlinear
thermodynamic
theory for the coupling behaviors of nanoporous
metals. The atomistic calculations will
simulate the strain-charge-chemical behaviors
of nanometer-thick films.
Successful completion of the proposed project
will facilitate the development of the thermodynamic
theory and nanotechnology, which will have
a high impact on both academic research
and engineering practice. The anticipated
output will become guidelines for the wide
application of nanomaterials and nanoporous
materials in high-tech industries.
Experimental Investigation of the Local
Balance Between Buoyant and Inertial Forces
in Turbulent Thermal Convection
Hong Kong Principal Investigator : Prof.
Xia Keqing (The Chinese University of Hong
Kong)
Mainland Principal Investigator : Prof.
Zhou Quan (Shanghai University)
An experimental project is proposed to study the relationship between buoyant forces and inertial forces over various scales in turbulent thermal convection over the Rayleigh number range 109 < Ra < 1011. The project aims to determine and understand the dynamics that drive the turbulent kinetic energy transport from large scales to small scales via simultaneous measurements of velocity and temperature differences over various real-space scales. The spatial distributions of local Bolgiano scale LB(x) and the local Kolmogorov (dissipative) scale η(x) at various values of Ra will also be investigated.
These objectives will be achieved by the combination of a non-standard high-resolution laser Doppler velocimetry (LDV) and a high-resolution multi-point thermometry technique. With the accessible parameter range of the apparatus we can test whether a balance between buoyant forces and inertial forces exist in the inertial range of scales in convective turbulence. The project will provide a rigorous experimental test on whether the Bolgiano-Obukhov (BO59) scaling, a long-existing model proposed in 1959 for the scaling of the cascades of the velocity and temperature fields in buoyancy-driven turbulence, exists in convective turbulent flows.
We expect the results coming out of this study to shed light on the nature of cascades from large to small scales of the turbulent kinetic energy and temperature variances in buoyancy-driven thermal turbulence, which is an important class of turbulent flows occurring ubiquitously in nature.