Project Title: Center for Genomic
Studies on Plant-Environment Interaction for
Sustainable Agriculture and Food Security
Project Coordinator: Prof Hon-ming Lam
(CUHK)
Abstract
To pursue international excellence on
innovative agriculture. Water scarcity,
global warming and topsoil depletion are
among the major factors hampering
sustainable agriculture and food security.
Here we have a strong team excelling in both
plant genomics and molecular biology, using
a multidisciplinary approach to address a
very fundamental question in plant and
agricultural sciences: how do plants
interact with their environment? The focus
of our research is to understand how plants
adapt to abiotic stresses and how plants
interact with microbes. We choose soybean as
our primary crop model due to its importance
in sustainable agriculture, our previous
successes in soybean genomic studies, the
availability of our soybean genomic sequence
database, unique germplasms and genetic
populations. New knowledge and technologies
acquired through the proposed research can
then be applied to other crops in
delineating the underlying mechanisms of
plant-environment interactions.
Endeavoring for sustainable agricultural research with high global impact. Aiming for long-lasting international impact, we will establish a stable soybean genetic population with precise annotated genomic information and online platform. We will study the genetic as well as redox regulation in relation to root growth under abiotic stress. We will thoroughly analyze the gene expression re-programming when plants are under abiotic stresses, with emphases on two new mechanisms that are at the forefront of current genomic researches: chromatin changes and non-coding RNAs. Since root nodule is a unique organ in legume plants that directly interacts with the soil, we will investigate the energy fluxes, gene expressions and RNA editing related to the functions of mitochondria in root nodules. Bilaterally, we will also study how several prevalent soybean cultivation systems impact the evolution of rhizobia in soil. The ultimate goals are to identify useful functional genes and effective DNA markers. We will make use of this information to generate prototypes of new adaptive soybean varieties by either transgenesis or marker-assisted breeding.
Develop cutting-edge technology with downstream applications. We pledge to deliver: (1) high-quality publications reporting important scientific findings; (2) a platform to disseminate genomic information to researchers and breeders; (3) prototypes of new varieties that are more adaptive to environmental challenges; (4) high-caliber trained personnel at the level of postdoctoral associates and graduate students who will be experts in the field of plant genomics and molecular biology; and (5) an international research network on crop sciences.
Project Title: Cellular mechanisms of
synaptic functions and plasticity in health
and neurodegenerative diseases
Project Coordinator: Prof Nancy Ip (HKUST)
Abstract
Neuronal synapses are critical for brain
function. Modulation of their strength,
termed synaptic plasticity, is essential
for connecting and maintaining the neural
network, and is the fundamental mechanism
underlying learning and memory. Loss of
synapses and their dysfunction are linked
to neurodegenerative diseases such as Alzheimer's
disease (AD), further highlighting their
importance. Synaptic plasticity is tightly
regulated and modulated by various biochemical
pathways, which are mediated by bidirectional
signaling between pre- and postsynaptic
neurons as well as communication between
neurons and glial cells such as astrocytes
and microglia. However, these processes
are poorly understood. Thus, deciphering
these specific mechanisms holds the key
to understanding the regulatory pathways
that mediate information flow in the neural
circuit and govern synaptic plasticity in
learning and memory.
To unravel the mechanisms underlying synaptic plasticity, we will examine the precise signaling and cellular mechanisms governing neuron-neuron and glial-neuron communication, which modulate synaptic functions and network connectivity as well as learning and memory. In particular, the cell population source of the receptor ligands within the neural circuit and the anatomical organization of these signaling pathways in the brain will be examined, and their effects on synaptic function and plasticity, neural circuit activity, and learning and memory will subsequently be investigated. Once we have determined the physiological roles of these key regulatory mechanisms, we will investigate how their deregulation contributes to the pathogenesis of neurodegenerative diseases, with a specific focus on AD. Restoring synaptic loss and function is a promising strategy for treating AD, and new insights and findings from the project will accelerate the development of biomarkers and synaptic repair strategies to prevent or delay cognitive dysfunctions in AD.
This project will lay crucial groundwork for delineating the mechanisms underlying learning and memory, and implicating key pathways and molecular players involved in cognitive dysfunction in neurodegenerative diseases such as AD. Successful completion of the project will greatly facilitate development of new therapies to tackle these incurable diseases, thereby improving the lives of millions of afflicted patients worldwide. The project will also enhance Hong Kong's growing reputation as a center of excellence for neuroscience and will highlight the territory's excellent scientific research capabilities, infrastructure, and highly skilled work force.
Project Title: Chemical Biology Approach
to Molecular Medicine
Project Coordinator: Prof Dan Yang (HKU)
Abstract
Chemical biology combines the power of synthetic
chemistry, chemical analysis, and biological
techniques to understand and manipulate
biological systems with molecular precision.
In contrast to biochemists who study the
chemistry of biomolecules and regulation
of biochemical pathways, chemical biologists
apply novel chemical compounds to probe
biological systems. Molecular design and
synthesis, molecular probes, chemical genetics,
chemical proteomics, molecular modelling
and structural biology are the key components
of chemical biology. In the past decade,
the rapid development of chemical biology
has not only provided numerous valuable
research tools to elucidate fundamental
biological mechanisms, but also prompted
the discovery of important therapeutic agents
to treat human diseases. Chemical biology
has emerged as a fast-growing and exciting
frontier of chemistry and is expected to
be a new driving force for important future
advances in molecular medicine and biotechnology.
The socioeconomic significance of chemical
biology research has been highlighted by
the vast amounts of resources invested by
top US universities such as Harvard, MIT,
Stanford, and Chicago to build up centres
of chemical biology research as well as
the introduction of chemical biology curriculum
in undergraduate education in UC Berkeley
and Harvard.
Hong Kong is ideally positioned to lead innovation in biotechnology through fundamental chemical biology research because of its excellent scientific expertise, especially in the chemistry and biomedical research. All universities in Hong Kong have recruited faculty members with chemical biology focus, many of them have been very active in frontier chemical biology research and achieved international pre-eminence. In this AoE proposal, PIs from three major universities of Hong Kong will join efforts to tackle challenging problems of molecular medicine via a chemical biology approach. Specifically, we plan to build up chemical biology research platforms, to understand fundamental biological processes (such as post-translational modification and oxidative stress) at molecular level, and to develop novel therapeutic approach to human diseases. The proposed AoE in chemical biology will significantly strengthen our current research efforts and collaborations, solve important problems of molecular medicine, maintain the competitive edge of Hong Kong, and build up a leading chemical biology program in the world.